the Master Hormone in Women

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When to Use Serenity

Progesterone is very well absorbed through the skin when it is in a properly formulated cream, such as Serenity Bio-Identical Progesterone Cream, and unlike orally taken progesterone it is not intercepted by the liver.

Serenity should be applied to the fatty tissue areas of the body where it is stored for use as needed:

  • face
  • neck
  • breasts
  • buttocks
  • thighs

Apply your cream to different areas of “freshly bathed” skin each time.

Most women feel a difference within a few minutes of initial application, however, those who are exceptionally deficient in progesterone and struggling with too much estrogen, may require 3 months to achieve an optimum balance.

A healthy woman should naturally produce 22-25 mg of progesterone per day in the second half of her monthly cycle (days 14-28). An eighth teaspoon of Serenity contains 15 mg of bio identical progesterone, so one application in the morning and one in the evening will constitute approximately 30 mg per day.

Allowing for stress and environmental toxins, you can expect to achieve not less than 22-25 mg per day, the amount that should be produced naturally. For severe symptoms a quarter teaspoon twice per day may be applied. The amount of cream you use will be ultimately determined by how you are feeling and how you are responding. Each jar contains more than 90 eighth-teaspoon applications.

Special Tip:

After each application of Serenity rub any residue on your face and neck You will be pleased with the improvement in skin tone.

* Please Note:

At the onset of using Natural Progesterone Cream some women may initially experience an increase in “oestrogen dominance” symptoms. This is due to the natural progesterone “waking up” oestrogen receptor sites not a reaction to progesterone. If experienced, simply reduce the amount of cream, and gradually return to a normal dose.  This condition is only temporary. As your body adjusts the re-introduction of this “most important” hormone, you will achieve an optimal balance and the symptoms caused by oestrogen dominance will ameliorate.

There are no reported short or long term side effects to using Serenity Bio Identical Progesterone Cream. – Too much oestrogen can cause irregular cycles and retention of old blood. Because Natural Progesterone has a normalizing effect on the menstrual cycle, it can initially promote the shedding of old blood. This shedding is very desirable as stored blood can increase the risk of endometriosis & endometrial cancer.


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Informed women have chosen the  the following:

If you are still having periods:

1/8th teaspoon mornings and at bed time days 14-28. Count the first day of bleed as day one of the cycle. If symptoms are severe you may initially use a quarter teaspoon mornings and evenings. If your cycle is not a normal 28 day cycle, then determine the day of ovulation and begin your cream that evening or the next morning.

HRT while still menstruating:

Dr. Lee recommends stopping HRT immediately at the outset of using Serenity. If, however, your symptoms are more than you are comfortable with, phase out the HRT over the following weeks or month or two. To phase out HRT you must determine whether the HRT you are taking is an oestrogen and progestin combination and, if so, change to an oestrogen-only HRT treatment. The use of Natural Progesterone concurrent with synthetic progesterone (Progestin) is to be avoided. If at any time you start a period, stop using the cream immediately, count that day as day 1, and start using the cream again on day 14. Serenity will not bring on a period if your body does not naturally require it.


(age 50+): An eighth teaspoon twice a day, mornings and bedtime for 25-26 consecutive days. Discontinue for 5-6 days. If symptoms are severe you may increase this dosage to a quarter teaspoon twice a day, but monitor progress and decrease as required. Using Serenity will not restart your menstrual cycle, as menopause is marked by the release of your last egg.


Same as Menopause above.

Menopause (surgically induced) and are currently taking HRT:

This is not age dependent. An eighth teaspoon twice a day, mornings and bedtime for 25-26 consecutive days. Discontinue for 5-6 days. If symptoms are severe you may increase this dosage to a quarter teaspoon twice a day, but monitor progress and decrease as required.


The use of Serenity in all women will stimulate osteoblast production which results in new bone tissue growth. Most osteoporosis sufferers will be menopausal and should use an eighth teaspoon mornings and an eighth teaspoon at bedtime for 25-26 days of the month and then discontinue for 5+6 days.

If you suffer from hot flushes or period related migraines:

For hot flushes, at the onset of a hot flush a dab of Serenity on the inside of each wrist may prove to be beneficial. At the onset of a migraine a dab behind each ear and on the temples have proved to be of great help. For migraine headaches, remove amalgam (mercury) dental fillings.


Progesterone is the pro-gestational hormone and necessary for conception and full-term pregnancy. Avoid environmental oestrogens.


Testosterone is the source of libido in women.  Progesterone is the precursor for testosterone.  Apply according to your menstrual status.

Persistent hot flushes/night sweats after using Serenity for a few weeks and after trying the increased dosage:

You will likely benefit from Natural Oestrogen Cream. Use once per day, only on the same days as your progesterone cream (you do not want to create oestrogen dominance) from one to all 25-26 days, as needed.


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