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Progesterone

Benefits of Progesterone

What is Progesterone & Who Needs It?

Progesterone is the Master Hormone in all women. It is the hormone responsible for balancing the activities of a woman’s 27 different estrogens. It is the hormone used by the body to make many other necessary hormones, including estrogen, allopregenalone & testosterone. Optimal progesterone levels, is foundational for a woman to enjoy good health & wellness.

Stephanie's Experience with Progesterone

  • If a cycling woman fails to maintain sufficient progesterone during β€œthat time of the month” she will experience some of the 150 symptoms of PMS/PMT, including cramping, irritability, headaches, etc…
  • A premature drop in Progesterone levels during pregnancy will almost always result in a miscarriage, or pre-term birth. A normal, sharp drop in progesterone levels on or about week 40, will trigger the birth of the baby & almost always result in β€œpost-partum depression”.
  • Progesterone stimulates bone building cells called osteoblasts to build new bone tissue more effectively than any other influence, including aerobic exercise. Bone loss in women, begins, on average at age 37, resulting in 1.5% bone mineral density loss per year.
  • Men need progesterone to make testosterone
  • Progesterone supports prostate health
  • Progesterone supports production of serotonin & has been labeled the β€œHappy Hormone”
  • Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females

Ending Endometriosis Naturally ~ Sara's Journey

Hormone Disruptors (the underlying cause)

A Tale of Two Progesterones

The journalΒ Postgraduate Medicine,Β 2009 Jan;121(1):73-85, stated, in part:

β€œPhysiological data and clinical outcomes demonstrate that bioidentical hormones are associated with lower risks, including the risk of breast cancer and cardiovascular disease, and are more efficacious than their synthetic and animal-derived counterparts. Until evidence is found to the contrary, bioidentical hormones remain the preferred method of HRT. Of special concern is their relative safety compared with traditional synthetic and animal-derived versions, such as conjugated equine estrogens (CEE), medroxyprogesterone acetate (MPA), and other synthetic progestins. Bioidentical hormones have some distinctly different, potentially opposite, physiological effects compared with their synthetic counterparts, which have different chemical structures. Both physiological and clinical data have indicated that progesterone is associated with a diminished risk for breast cancer, compared with the increased risk associated with synthetic progestins.” linkΒ [mfn]The bioidentical hormone debate: are bioidentical hormones (estradiol, estriol, and progesterone) safer or more efficacious than commonly used synthetic versions in hormone replacement therapy?

Two Awesome Progesterone Articles!

The History of Natural Progesterone the Never-Ending Story

(pubmed.gov)

β€œSlowing the Aging Process with Natural Progesterone”

John Lee MD – Author Pioneer in Use of Natural Progesterone

Biology of Progesterone for Both Genders

  • Differentiating Between Natural Progesterone and Synthetic Progestins: Why Important Β link2Β linkΒ 3Β link4
  • Progesterone Supports a Healthy HeartΒ link5
  • Progesterone supports the brain to heal from damage after traumatic brain injuryΒ (the Human Brain Has an Inordinately Large Number of Progesterone Receptor Sites)Β linkΒ 6Β link7Β link8Β link9
  • Progesterone is the precursor for AllopregnanaloneΒ (the nervous system has the capacity to bio-convert progesterone into its active metabolite allopregnanolone. The enzymes required for progesterone and allopregnanolone synthesis are widely distributed in brain and spinal cord. Increased local biosynthesis of pregnenolone, progesterone and 5Ξ±-dihydroprogesterone may be a part of an endogenous neuroprotective mechanism in response to nervous system injuries. Progesterone and allopregnanolone neuroprotective effects have been widely recognized)Β link10
  • β€œProgesterone prevented membrane cell damage, motoneuron loss and cell death.Β Allopregnanolone treatment was also neuroprotective.” link11
  • Progesterone supports the body to normalize the symptoms of Multiple SclerosisΒ link12
  • Progesterone Supports a Happy Mood, via Allopregnanolone ProductionΒ link13
  • Progesterone Supports a Healthy HeartΒ linkΒ 14Β llink15
  • FacilitatesΒ thyroid hormone function and utilization β€œEstrogen dominance causes the liver to produce high levels of a protein called β€œthyroid binding globulin”, which, as its name suggests, binds the thyroid hormone and decreases the amount of thyroid hormone that can be assimilated into and utilized by the cells.What does this lead to? Low thyroid function and all of the negative side effects that come along with it.”  link16link17linkΒ 18Β link19
  • Progesterone is Anti-estrogenicΒ (the average 54 year old male in the US, has higher estrogen levels that the average 54 year old female!)Β link20
  • Progesterone Supports Normal, Programmed Cell Replacement in breast,Β ovarian & prostate tissuesΒ link21link22Β link23Β linkΒ 24
  • Progesterone Supports the Body’s Natural Process of Inhibiting Tumor FormationΒ in Breast & Prostate CellsΒ link2526
  • Progesterone receptor modulates estrogen receptor-Ξ± action in breast cancerΒ link28Β link29Β link30
  • Progesterone Supports the Body’s Ability to Alleviate the underlying cause of Hot FlashesΒ link31Β linkΒ 32
  • Progesterone Supports the Activity of Osteoblast CellsΒ (in US, women, on average, lose 1.5% bone/year) (bone health)Β β€œProgesterone plus estradiol or other anti-resorptive therapies adds 0.68%/year and may be a highly effective osteoporosis treatment. US average is 1.5% bone loss/year” link33
  • Progesterone as a Bone-Trophic HormoneΒ link34Β link35
  • Progesterone Supports Phase IV sleep (the restorative, restful sleep)Β link36Β link37Β link38

Biology of Progesterone for Women

  • Differentiating Between Natural Progesterone and Synthetic Progestins: Why Important Β link39
  • Progesterone vs. synthetic progestins: a systematic review and meta-analysisΒ (a study involving 86,881 postmenopausal women)Β link40
  • Progesterone Supports Fertility, Conception, Full-Term PregnancyΒ link41Β link42link43link44
  • High Levels of Progesterone During PregnancyΒ link45
  • ProgesteroneΒ Supports the body’s ability to correct the underlying cause of most of the 150 different symptoms of PMS/PMDDΒ link46
  • Progesterone FacilitatesΒ thyroid hormone function and utilization β€œEstrogen dominance causes the liver to produce high levels of a protein called β€œthyroid binding globulin”, which, as its name suggests, binds the thyroid hormone and decreases the amount of thyroid hormone that can be assimilated into and utilized by the cells.What does this lead to? Low thyroid function and all of the negative side effects that come along with it.”  link47link48linkΒ 49linkΒ 50
  • Progesterone Supports a Woman’s Normal Libido (Progesterone is the Precursor for Testosterone,source of libido in women)link51Β link52Β link53Β link54
  • ProgesteroneΒ Supports Healthy, Happy OvariesΒ (lol)Β link55Β link56Β linkΒ 57Β link58
  • Progesterone Supports Normal, Programmed Cell Replacement in breast & ovarian tissues linkΒ 59Β link60link61Β linkΒ 62Β link63
  • Progesterone Supports a Healthy EndometriumΒ link64Β linkΒ 65
  • Progesterone SupportsΒ Inhibition of Tumor FormationΒ in Breast CellsΒ link66Β link67Β link68Β link69Β link70
  • ProgesteroneΒ Supports women in MenopauseΒ link71
  • ProgesteroneΒ Alleviates the underlying cause of Hot FlashesΒ link72Β link73
  • Supports Osteoblast FunctionΒ (bone health)Β β€œProgesterone plus estradiol or other anti-resorptive therapies adds 0.68%/year and may be a highly effective osteoporosis treatment. US average is 1.5% loss/year” link74
  • Progesterone as a Bone-Trophic HormoneΒ link75Β link76
  • Progesterone Supports Phase IV sleep (the restorative, restful sleep)Β link77Β linkΒ 78Β link79
  • Progesterone protects the brain from damage after traumatic brain injuryΒ link80Β link81
  • Progesterone is the Precursor to Allopregnanolone Supports a Happy MoodΒ linkΒ 82

Biology of Progesterone for Men

  • Progesterone is the Precursor for TestosteroneΒ link83Β link84
  • TestosteroneΒ Supports Improved Muscle MassΒ link85
  • TestosteroneΒ Supports Weight LossΒ link86
  • TestosteroneΒ Strengthens BonesΒ link87
  • Testosterone Supports a Healthy HeartΒ link88
  • TestosteroneΒ Fuels LibidoΒ link89
  • TestosteroneΒ Supports an E.D.-Free Life!Β link90Β linkΒ 91Β linkΒ 92Β linkΒ 93
  • TestosteroneΒ Supports a Decrease Alzheimer’s Risk & Improves Cognitive FunctionΒ linkΒ 94Β linkΒ 95
  • TestosteroneΒ Supports Increased Athletic PerformanceΒ linkΒ 96
  • TestosteroneΒ Supports Increased Hemoglobin (low hemoglobin=anemia)Β linkΒ 97
  • TestosteroneΒ Supports Male Magnetism Toward WomenΒ linkΒ 98
  • ProgesteroneΒ Supports Normal Breast Size in Men (links coming soon)
  • ProgesteroneΒ Blocks 5AR, the Enzyme that Converts a Man’s Valuable Testosterone to DHT (normal consequence of aging). DHT is Implicated in an Elevated PSA Count (links coming soon)
  • ProgesteroneΒ Is a Proven, Successful Treatment for Traumatic Brain Injury (links coming soon)
  • The Human Brain Has an Inordinately Large Number of Progesterone Receptor Sites, Ergo,Β ProgesteroneΒ Supports a Balanced Brain Chemistry (links coming soon)
  • Repeat:Β Progesterone is the Precursor for TestosteroneΒ link99Β link100

Clarification of a Long-Standing Misconception

It is important to note, there are two progesterones, one made by the body and one that is molecularly altered and patentable. It is a common practice for health care professionals to say β€œprogesterone” when referring to the synthetic β€œprogestin”. This is an important distinction, as β€œprogestins” have a litany of side-effects.Β Conversely, β€œbiologically identical progesterone” has a 40+ year history of safe, effective use, when administered in a safe cream formula.

ACKNOWLEDGEMENTS

To those who came before us: Β We would like to take a moment to honor and appreciate your dedication and service to the world. Among them, two very important people must be mentioned. These devoted men pioneered the study of women’s health and the use of bio identical hormones. First, our primary personal Mentor and Friend was Dr. John R. Lee, M.D. Dr. Lee, was internationally acknowledged as a pioneer and expert in the study and use of the hormone progesterone, and on the subject of hormone replacement therapy for women. He used transdermal progesterone extensively in his clinical practice for 20 years, doing research which showed that it can reverse osteoporosis. Dr. Lee also famously coined the term β€œestrogen dominance,” meaning a relative lack of progesterone compared to estrogen, which causes a list of symptoms familiar to millions of women. Dr. Lee had a distinguished medical career, including graduating fromΒ HarvardΒ and theΒ University of Minnesota Medical School. After he retired from a 30-year family practice in Northern California he began writing and traveling around the world speaking to doctors, scientists and lay people about progesterone. Dr. Lee also taught a very popular course on β€œOptimal Health,” at the College of Marin for 15 years, for which he wrote the bookΒ Optimal Health Guidelines. His second self-published book, written for doctors, wasΒ Natural Progesterone: The Multiple Roles of a Remarkable Hormone.Β He then teamed up with Virginia Hopkins and others to write the best-selling books: WHAT YOUR DOCTOR MAY NOT TELL YOU ABOUT MENOPAUSE: The Breakthrough Book on Natural ProgesteroneΒ (Warner Books, 1996) WHAT YOUR DOCTOR MAY NOT TELL YOU ABOUT PREMENOPAUSE: Balance Your Hormones and Your Life from Thirty to FiftyΒ (Warner Books, 1999) WHAT YOUR DOCTOR MAY NOT TELL YOU ABOUT BREAST CANCER: How Hormone Balance Can Help Save Your Life,Β (Warner Books, 2002) Second, we’d like to take a moment to thank Dr. Ray Peat PhD. Dr Peat has a Ph.D. in Biology from the University of Oregon, with specialization in physiology. The schools where he has taught include: the University of Oregon, Urbana College, Montana State University, National College of Naturopathic Medicine, Universidad Veracruzana, the Universidad AutΓ³noma del Estado de MΓ©xico, and Blake College. He also conducts private nutritional counseling. Dr. Peat started his work with progesterone and related hormones in 1968. In his papers on Physiological Chemistry and Physics (1971 & 1972) and in his dissertation (University of Oregon, 1972), he outlined his findings regarding progesterone, and the hormones closely related to it, as protectors of the body’s structure and energy against the harmful effects of estrogen, radiation, stress, and lack of oxygen. The key idea was that energy and structure are interdependent, at every level. We resonate greatly with many of the statements Dr. Peat makes: β€œβ€Marketing” of these as products, without understanding just what they do and why they do it, seems to be adding confusion, rather than understanding, as hundreds of people sell their misconceptions with their products. The very concept of β€œmarketing” is at odds with the real nature of these materials, which has to do with the protection and expansion of our nature and potential. A distorted idea of human nature is sold when people are treated as β€œthe market.” It seems that all of the problems of development and degeneration can be alleviated by the appropriate use of the energy-protective materials. When we realize that our human nature is problematic, we can begin to explore our best potentials.” We feel very privileged to have role models like Dr. Lee and Dr. Peat who pioneered the pathway of empowering the lives of women and beyond, with the safe use of bio identical progesterone. The education and research they’ve provided has been founded on integrity and a commitment to improving the lives of others. We’ve worked with and seen first hand for more than two decades, the value these men have brought to the lives of millions.

It is our Mission to continue the Legacy!

REFERENCES

Stein DG.Β The case for progesterone.Β Ann NY Acad Sci. 2005 Jun;1052:152-69. Hotze SF.Β Hormones, Health, and Happiness.Β Houston, TX: Forrest Publishing; 2005. Syst Rev. 2016; 5: 121. Published online 2016 Jul 26. doi: 10.1186/s13643-016-0294-5 PMCID: PMC4960754 PMID: 27456847.Β Progesterone vs. synthetic progestins and the risk of breast cancer: a systematic review and meta-analysis.Β Noor Asi,corresponding author1,7 Khaled Mohammed,1 Qusay Haydour,1,2 Michael R. Gionfriddo,3 Oscar L. Morey Vargas,4 Larry J. Prokop,5 Stephanie S. Faubion,6 and Mohammad Hassan Murad1 Files JA, Ko MG, Pruthi S.Β Bioidentical hormone therapy.Β Mayo Clin Proc. 2011;86:673–680. doi: 10.4065/mcp.2010.0714. [PMC free article] [PubMed] [CrossRef] [Google Scholar] Stanczyk FZ, Hapgood JP, Winer S, Mishell DR., Jr.Β Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects.Β Endocr Rev. 2013;34:171–208. doi: 10.1210/er.2012-1008. [PMC free article] [PubMed] [CrossRef] [Google Scholar] Progestins.Β LiverTox: Clinical and Research Information on Drug-Induced Liver InjuryΒ [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. 2019 Jun 6. PMID: 31643562 Chitturi S, Farrell GC.Β Adverse effects of hormones and hormone antagonists on the liver.Β In, Kaplowitz N, DeLeve LD, eds. Drug-induced liver disease. 2nd ed. New York: Informa Healthcare USA, 2007, pp. 707-22. (Review of hepatotoxicity of female sex hormones published in 2007 states that progestin-only contraceptives or high dose progestin regimens used in breast cancer may rarely produce cholestasis). Adlercreutz H, Tenhunen R. Some aspects of the interaction between natural and synthetic female sex hormones and the liver.Β Am J Med 1970; 49: 630-48. [PubMed] (Review of the hepatic effects of synthetic estrogens and progestins states that β€œintrahepatic cholestasis and jaundice… have been reported only for progestogens with the 19-norsteroid configuration”).

Reproductive Hormone Market Predicts Steady Growth Till 2027

Top Leading Companies:Β Pfizer, Allergan, Bayer, MERCK Groups, Jenapharm, ABBVIE, Xianju Pharma,Mayne Pharma